首頁 > 論文 > 光學學報 > 39卷 > 12期(pp:1223004--1)

具有中紅外光通道的生物探針的制備及性能

Fabrication and Characterization of Bioprobe with Mid-Infrared Light Channel

  • 摘要
  • 論文信息
  • 參考文獻
  • 被引情況
  • PDF全文
分享:

摘要

提出一種基于空芯光纖,兼具導電和中遠紅外傳光性能的生物探針,實現波長5~10 μm處光的低損耗傳輸。采用環烯烴聚合物(COP)對探針前端進行水密封,并對封口工藝進行設計和優化。采用波長5.1 μm的光源測得長度為20 cm、內徑/外徑(ID/OD)為0.7 mm/1.5 mm探針的損耗為1.38 dB。通過控制封口工藝,制備不同形狀的COP封口窗片,實現對輸出光束的調控。通過測量不同形狀封口窗片的輸出光斑,分析探針的焦距及光束遠場發散角,為神經科學研究和生物醫學應用提供更多的途徑和手段。

Abstract

Herein, a bioprobe based on hollow fibers with electrical and optical delivery channels is proposed to realize low attenuation transmission of mid-infrared light at the wavelength band ranging from 5 μm to 10 μm. Cyclic olefin polymer (COP) is used to isolate the front-end of the probe from water and the necessary sealing technology is designed and optimized. The loss of bioprobe with length of 20 cm and inner diameter/outer diameter (ID/OD) of 0.7 mm/1.5 mm is 1.38 dB at a wavelength of 5.1 μm. By controlling the sealing process, COP sealed windows with different shapes are fabricated to modify the output beam. The focal length and far-field divergence angle for these different configurations are analyzed by measuring the output beam profiles. This approach will provide more ways and means for neuroscience research and biomedical application.

Newport宣傳-MKS新實驗室計劃
補充資料

中圖分類號:TN214

DOI:10.3788/AOS201939.1223004

所屬欄目:光學器件

收稿日期:2019-07-02

修改稿日期:2019-08-08

網絡出版日期:2019-12-01

作者單位    點擊查看

彭傳迪:復旦大學電磁波信息科學教育部重點實驗室, 上海 200433
??≌?/b>:軍事科學院國防科技創新研究院前沿交叉技術研究中心, 北京 100071
朱曉松:復旦大學電磁波信息科學教育部重點實驗室, 上海 200433
常超:軍事科學院國防科技創新研究院前沿交叉技術研究中心, 北京 100071
石藝尉:復旦大學電磁波信息科學教育部重點實驗室, 上海 200433

聯系人作者:石藝尉([email protected])

【1】Zhang W D, Li X, Bai J H, et al. Generation and application of fiber-based structured light field [J]. Acta Optica Sinica. 2019, 39(1): 0126003.
張文定, 李鑫, 白家浩, 等. 光纖結構光場產生及應用 [J]. 光學學報. 2019, 39(1): 0126003.

【2】Li R F, Shi K B. High spatiotemporal imaging based on optical field engineering [J]. Acta Optica Sinica. 2019, 39(1): 0126010.
李潤豐, 施可彬. 基于光場調控的高時空分辨率光學成像 [J]. 光學學報. 2019, 39(1): 0126010.

【3】Alt M T, Fiedler E, Rudmann L, et al. Let there be light: optoprobes for neural implants [J]. Proceedings of the IEEE. 2017, 105(1): 101-138.

【4】Iwai K, Hongo A, Takaku H, et al. Fabrication and transmission characteristics of infrared hollow fiber based on silver-clad stainless steel pipes [J]. Applied Optics. 2009, 48(32): 6207-6212.

【5】Iwai K, Takaku H, Miyagi M, et al. Fabrication of shatter-proof metal hollow-core optical fibers for endoscopic mid-infrared laser applications [J]. Fibers. 2018, 6(2): 24.

【6】Kiss M, F?ldesy P, Fekete Z. Optimization of a Michigan-type silicon microprobe for infrared neural stimulation [J]. Sensors and Actuators B: Chemical. 2016, 224: 676-682.

【7】Castonguay A, Thomas S, Lesage F, et al. Optogenetic tools for confined stimulation in deep brain structures[M]. ∥Kianianmomeni A. Optogenetics: , 2016, 1408: 267-279.

【8】Perkins L N, Semu D, Shen J, et al. High-density microfibers as a potential optical interface to reach deep brain regions [J]. Journal of Neural Engineering. 2018, 15(6): 066002.

【9】Chamanzar M, Garfield D J, Iafrati J, et al. Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging [J]. Biomedical Optics Express. 2018, 9(9): 4359-4371.

【10】Zhao Y, Liu C B, Liu Z X, et al. Wirelessly operated, implantable optoelectronic probes for optogenetics in freely moving animals [J]. IEEE Transactions on Electron Devices. 2019, 66(1): 785-792.

【11】Yu S Y, Chiu J H, Yang S D, et al. Biological effect of far-infrared therapy on increasing skin microcirculation in rats [J]. Photodermatology, Photoimmunology and Photomedicine. 2006, 22(2): 78-86.

【12】Jeong Y M, Cheng X W, Lee S, et al. Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways [J]. Scientific Reports. 2017, 7: 13718.

【13】Chen C H, Chen T H, Wu M Y, et al. Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice [J]. Scientific Reports. 2017, 7: 40442.

【14】Wang J L, Lin Y C, Young T H, et al. Far-infrared ray radiation promotes neurite outgrowth of neuron-like PC12 cells through AKT1 signaling [J]. Journal of the Formosan Medical Association. 2019, 118(2): 600-610.

【15】Chiang I, Pu Y, Young T. P-46-photomodulation and protective effects of far infrared irradiation to cultivation of renal poximal tubule cell [J]. European Urology Supplements. 2018, 17(10): e2546.

【16】Li K, Zhang Z, Liu N F, et al. Efficacy and safety of far infrared radiation in lymphedema treatment: clinical evaluation and laboratory analysis [J]. Lasers in Medical Science. 2017, 32(3): 485-494.

【17】Li K, Zhang Z, Liu N F, et al. Far-infrared radiation thermotherapy improves tissue fibrosis in chronic extremity lymphedema [J]. Lymphatic Research and Biology. 2018, 16(3): 248-257.

【18】Chen C F, Chen F A, Tan A C, et al. Far-infrared therapy improves ankle brachial index in hemodialysis patients with peripheral artery disease [J]. Heart and Vessels. 2019, 34(3): 435-441.

【19】Tan Z, Liao C R, Liu S, et al. Simultaneous measurement sensors of temperature and strain based on hollow core fiber and fiber Bragg grating [J]. Acta Optica Sinica. 2018, 38(12): 1206007.
譚展, 廖常銳, 劉申, 等. 基于空芯光纖和光纖布拉格光柵的溫度應變同時測量傳感器 [J]. 光學學報. 2018, 38(12): 1206007.

【20】Lin H, Zhang X, Zhu X S, et al. Refractive index sensor based on hollow optical fiber with metal-dielectric-metal multilayered films structure [J]. Acta Optica Sinica. 2018, 38(6): 0606006.
林華, 張嫻, 朱曉松, 等. 基于金屬-介質-金屬多層膜結構的空芯光纖折射率傳感器 [J]. 光學學報. 2018, 38(6): 0606006.

【21】Garmire E. McMahon T, Bass M. Low-loss optical transmission through bent hollow metal waveguides [J]. Applied Physics Letters. 1977, 31(2): 92-94.

【22】Zeng X, Liu B H, He Y J, et al. Fabrication and characterization of AgI/Ag hollow fibers for near-infrared lasers [J]. Optics & Laser Technology. 2013, 49: 209-212.

【23】George R, Harrington J A. Infrared transmissive, hollow plastic waveguides with inner Ag-AgI coatings [J]. Applied Optics. 2005, 44(30): 6449-6455.

【24】Hongo A, Sato S, Hattori A, et al. AgI-coated silver-clad stainless steel hollow waveguides for infrared lightwave transmission and their applications [J]. Applied Optics. 2012, 51(1): 1-7.

【25】Liu B H, Jiang Y X, Zhu X S, et al. Hollow fiber surface plasmon resonance sensor for the detection of liquid with high refractive index [J]. Optics Express. 2013, 21(26): 32349-32357.

【26】Alaluf M, Dror J, Croitoru N I. Plastic hollow waveguides as transmitters and filters in mid-IR radiation [J]. Proceedings of SPIE. 1992, 1591: 146-151.

【27】Matsuura Y, Saito M, Miyagi M, et al. Loss characteristics of circular hollow waveguides for incoherent infrared light [J]. Journal of the Optical Society of America A. 1989, 6(3): 423-427.

【28】Miyagi M, Kawakami S. Design theory of dielectric-coated circular metallic waveguides for infrared transmission [J]. Journal of Lightwave Technology. 1984, 2(2): 116-126.

【29】Tang J F, Gu P F, Liu X, et al. Modern optical thin film technology[M]. Hangzhou: Zhejiang University Press, 2006.
唐晉發, 顧培夫, 劉旭, 等. 現代光學薄膜技術[M]. 杭州: 浙江大學出版社, 2006.

【30】Sui K R, Shi Y W, Tang X L, et al. Optical properties of AgI/Ag infrared hollow fiber in the visible wavelength region [J]. Optics Letters. 2008, 33(4): 318-320.

【31】Shi Y W, Ito K, Ma L, et al. Fabrication of a polymer-coated silver hollow optical fiber with high performance [J]. Applied Optics. 2006, 45(26): 6736-6740.

【32】Washburn E W. The dynamics of capillary flow [J]. Physical Review. 1921, 17(3): 273-283.

【33】Deegan R D, Bakajin O, Dupont T F, et al. Capillary flow as the cause of ring stains from dried liquid drops [J]. Nature. 1997, 389(6653): 827-829.

【34】Zhou B K, Gao Y Z, Chen T R, et al. The principle of laser[M]. Beijing: National Defense Industry Press, 2009.
周炳琨, 高以智, 陳倜嶸, 等. 激光原理[M]. 6版. 北京: 國防工業出版社, 2009.

引用該論文

Peng Chuandi,Zheng Junzhe,Zhu Xiaosong,Chang Chao,Shi Yiwei. Fabrication and Characterization of Bioprobe with Mid-Infrared Light Channel[J]. Acta Optica Sinica, 2019, 39(12): 1223004

彭傳迪,??≌?朱曉松,常超,石藝尉. 具有中紅外光通道的生物探針的制備及性能[J]. 光學學報, 2019, 39(12): 1223004

您的瀏覽器不支持PDF插件,請使用最新的(Chrome/Fire Fox等)瀏覽器.或者您還可以點擊此處下載該論文PDF

{ganrao}